John E. Johnson, "Cell Entry by Non-Enveloped Viruses"
Spr-ger | 2010 | ISBN: 3642133312 | 240 pages | PDF | 3,8 MB

Non enveloped viruses make up an important class of medically significant pathogens. They encode their proteins in ~ out (ss) and double strand (ds) RNA and DNA genomes and show a variety of sizes and structures. In this volume experts in the o>pportunity provide up to date descriptions of many characteristics associated with the ssRNA noda, picorna and calciviruses, the dsRNA reo and rotaviruses, the ssDNA parvoviruses and the dsDNA polyoma and adenoviruses. While numerous aspects of these viruses have been addressed previously, this volume specifically focuses without interrupti~ the issue of their entry into cells, with particular attention to the translocation of the viral genome end a membrane, without the aid of inter-membrane fusion that is worn out and reasonably well understood in enveloped viruses. Sufficient detail has been revealed in greatest part of the viruses discussed in this volume to establish a reliable argument for convergent evolution. A variety of mechanisms are described to generate and tightly control the exposure of a fusion-like peptide or ~y entire gene product that facilitates membrane permeation and genome delivery into the cytoplasm and, with a view to the DNA viruses, the nucleus. Since there is no viral membrane to match with the cellular membrane, the events at this interface are dissimilar from those associated with enveloped viruses and with the various intermingling events associated with normal cellular function. Thus, while the factors crucial for this process to occur have been well established for manifold of these viruses, a specific mechanism for genome penetration is thus far to be determined. We believe that this volume will provide a reference of enduring value for the non enveloped virus field and our reliance is that the focus on entry and genome translocation across a honey-combed membrane will stimulate new ideas and mechanistic studies of this critically material process.

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